It’s time to go on document with Week 16 NFL picks in opposition to the unfold.

Stats are courtesy of TruMedia and Pro Football Focus until in any other case famous.

This column publishes Thursday morning. Note: If there are important line adjustments resulting from gamers happening the reserve/COVID-19 checklist later within the week, examine again right here for up to date picks.

Last week: 11-5

Season: 118-104-2

San Francisco 49ers at Tennessee Titans (+3) | 8:20 p.m. ET Thursday, NFLN

Barring one thing sudden, the 49ers are going to be within the playoffs as a wild-card staff. It’s only a matter of the place they’re seeded. Right now, they’re sixth and two video games behind the fifth-seeded Los Angeles Rams. The two groups play one another in Week 18. San Francisco’s offense is potent when George Kittle and Deebo Samuel are wholesome and has quietly jumped all the way up to fourth in Football Outsiders’ DVOA metric.

The Titans turned the ball over 4 instances of their loss to the Pittsburgh Steelers final week however must fully collapse to fall out of first place within the AFC South. They have a one-game lead over the

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